• 800.553.2400
  • 0

    You have no items in your shopping cart.

Review the Research for Dogs, Cats and Small Animals

Since 1996 we have been focused on researching the role of nutrition in animal health and developing superior quality formulas based on research and clinical experience. Over the past two decades our team of nutritionists, Ph.Ds and veterinarians have learned a lot about the power of nutrition. We're committed to providing our clients with the tools and information needed to benefit from nutrition and supplementation.

Research White Papers

DTO Smectite for the Intestinal Health and Well-Being of Small Animals

Tara Hembrooke, Ph.D., M.S.

Under normal circumstances, a delicate balance exists between the nonpathogenic microflora that normally reside in the intestinal tract and the pathogenic microbes that release toxins and cause clinical disease. Some of the pathogenic organisms that are of concern in small animals are Clostridium difficile, Clostridium perfringens, Salmonella spp., and Campylobacter spp.1-3

Summary
DTO smectite, an intestinal adsorbant, may help create an intestinal environment that protects against the harmful effects of microbial overgrowth and toxin production.

Putting it Into Practice
Supplement dogs and cats affected by diarrhea with DTO smectite to help support gastrointestinal health.

Literature Cited
  1. Fox J. Enteric and other bacterial infections In: Greene C, ed. Infectious diseases of the dog and cat. Philadelphia: WB Saunders Co, 1990;538-548.
  2. Guilford W, Strombeck D. Gastrointestinal tract infections, parasites, and toxicoses In: Guilford W, Center S, Strombeck D, et al., eds. Strombeck’s Smallanimalgastroenterology.3rded.Philadelphia:WBSaundersCo, 1996;411-415.
  3. Marks SL. Diagnostic and therapeutic approach to cats with chronic diarrhoea. J Fel Med Surg 2000;2:105-109.

Supplementation for Healthy Skin and Coat

Tara Hembrooke, Ph.D., M.S.

The skin is the largest organ in the body with a high metabolic activity and, thus, has a large energy requirement. Even slight deviations in nutrient intake can have significant, and very obvious, deleterious effects on the skin. In addition to maintaining a balanced diet, supplementation with various nutrients can positively impact the overall health of the skin and prevent common disorders such as skin allergies and immune-related reactions.

Summary
Allergic reactions are characterized by an immune-mediated inflammatory response to an often- benign stressor. Among dogs, various types of allergies are commonly reported, such as contact, food, flea, bacteria, and atopic. Allergen exposure is rather ubiquitous, and allergic reactions can be more than just a nuisance to the dog. A balanced diet is critical, especially as the skin regenerates rapidly and provides the “first line” defense against environmental factors. Additional supplementation with omega-3 fatty acids, antioxidants, vitamins, trace minerals and immune-enhancing nutrients can provide further protection for the health and well- being of the dog.

Putting it Into Practice

  • As a measure against skin and other allergic problems, supplement canine diets with omega-3 fatty acids, trace minerals, vitamins and antioxidants.
  • During times of high allergen exposure or allergic reactions, provide DHA, purified thymus protein and Quercetin.

Feeding to Reduce Oxidative Damage and Improve Cognitive Function

Tara Hembrooke, Ph.D., M.S.

Free radicals are produced either as a result of normal metabolism or as part of the inflammatory response to infections,1 intense exercise,2 ultraviolet light3 and ingestion of rancid fats.4-5 Free radicals damage structures in the body, like proteins, fats and DNA,6 and are associated with several canine diseases. Although free radicals are believed to increase naturally with the aging process,7-9 excessive accumulation of free radicals and damage to lipids and protein may contribute to forms of canine senility, as has been reported for dogs with a canine form of Alzheimer’s.10

Summary
Although antioxidant supplementation has been recommended to reduce the decline in learning and memory that naturally occurs in elderly dogs, there is evidence that younger dogs benefit from both omega-3 fatty acid and antioxidant supplementation. In a controlled study, supplementation with a commercially available omega-3, antioxidant, and micronutrient product improved learning and memory in middle-aged dogs, which could have been due to the improvement in antioxidant systems and decrease in levels of damaged lipids and proteins.

Literature Cited
  1. Pattanaik U, Prasad K. Reactive oxygen species and endotoxic shock: effect of dimethylthiourea. J Cardiovasc Pharmacol Ther 2001;6:273-285.
  2. Wyse C, Cathcart A, Sutherland R, et al. Effect of maximal dynamic exercise on exhaled ethane and carbon monoxide levels in human, equine, and canine athletes. Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 2005;141:239-246.
  3. Vinson JA. Oxidative stress in cataracts. Pathophysiology 2006;13:151-162.
  4. Hageman G, Verhagen H, Schutte B, et al. Biological effects of short- term feeding to rats of repeatedly used deep-frying fats in relation to fat mutagen content. Food Chem Toxicol 1991;29:689-698.
  5. Izaki Y, Yoshikawa S, Uchiyama M. Effect of ingestion of thermally oxidized frying oil on peroxidative criteria in rats. Lipids 1984;19:324-331.
  6. Sizer F, Whitney E. Nutrition: concepts and controversies. 7th ed. Belmont: Wadsworth Publishing Co., 1997.
  7. HarmanD.Aging:atheorybasedonfreeradicalandradiationchemistry. J Gerontol 1956;11:298-300.
  8. FlemingJ,MiquelJ,CottrellS,etal.Iscellagingcausedbyrespiration- dependent injury to the mitochondrial genome? Gerontology 1982;28:44-53.
  9. AmesB,ShigenagaM,HagenT.Oxidants,antioxidants,andthe degenerative diseases of aging. Proc Natl Acad Sci 1993;90:7915-7922.
  10. SkoumalovaA,Ro naJ,SchwippelovaZ,etal.Theroleoffreeradicals in canine counterpart of senile dementia of the Alzheimer type. Exp Gerontol 2003;38:711-719.

Diet, Health and Defense Against Inflammation

Tara Hembrooke, Ph.D., M.S.

Every function in a dog’s body is controlled by genes, and nutrition significantly affects how these genes are expressed. This area of study, called nutragenomics, is also being investigated in humans with chronic diseases.1 A common focus of nutragenomics is investigation of the effects of diet on inflammation in the body and its role in the development or progression of disease.

Summary
Supplementing canine diets with omega-3 fatty acids, antioxidants and particular micronutrients decreased expression of the pro-inflammatory cytokine, IL-1beta, and increased expression of the anti-inflammatory cytokine, IL-10. Modulating inflammation through cytokine expression may help regulate the inflammatory component of various canine diseases and disorders, which may be achieved by maintaining dogs on an anti- inflammatory diet.

Putting it Into Practice

  • Reduce dog foods with excessive omega-6 fatty acids as compared to omega-3 fatty acids.
  • To maintain healthy cognitive function supplement the canine diet with omega-3 fatty acids, antioxidants and other essential micronutrients.
Literature Cited
  1. Kaput J. Diet–disease gene interactions. Nutrition 2004;20:26-31.

Request a Copy!

If you would like to receive a copy of a Research White Paper, please contact a Platinum Advisor at 800-553-2400.

Platinum Advisors

Experts Who Care About Canine and Feline Nutrition

Questions about nutrition? Platinum Advisors are specialists in nutrition and experienced pet owners who can help you find the answers and resources for your questions.

800-553-2400