Maintaining Normal Healthy Levels of
Inflammation in the Equine Body

At the cellular level, metabolites of omega-3 fatty acids are anti-inflammatory; whereas, metabolites of omega-6 fatty acids are pro-inflammatory. While horses in the wild consume up to five times as many omega-3 fatty acids as omega-6 fatty acids, many of today's grains and complete feeds contain far fewer omega-3 and more omega-6 fatty acids. This dietary imbalance may predispose the horse to excessive inflammation, which has been implicated in diseases such as arthritis, laminitis, colic, and colitis.

Nutritional Solutions to Support Your Patients

See our recommended Platinum Protocols for common equine conditions and injuries.

Condition Products Protocol
Overall Wellness
  • Platinum Performance® Equine or
    Platinum Performance® CJ
Administer 1 scoop of Platinum Performance® Equine or Platinum Performance® CJ BID.
  • Platinum Performance® Equine
  • Platinum Skin & Allergy
Administer 1-2 scoops of Platinum Performance® Equine BID and 1 heaping scoop of Platinum Skin & Allergy BID.
  • Platinum Comfort or
    Platinum Vet Joint Support
Administer 2 level scoops of Platinum Comfort BID or 1 level scoop of Platinum Vet Joint Support BID.
  • Platinum Performance® Equine
  • Hemo-Flo®
  • Magnesium Citrate
  • Platinum Antioxidant
  • Platinum Hoof Support
Make appropriate diet and medical recommendations and administer 2-3 scoops of Platinum Performance® Equine BID. Administer 1 level scoop of Hemo-Flo® BID, 2 rounded scoops of Magnesium Citrate BID, 1 rounded scoop of Platinum Antioxidant BID, and 1 level scoop of Platinum Hoof Support BID.
Wound Healing
  • Platinum Performance® Equine
Administer 1-3 scoops of Platinum Performance® Equine BID.

SID = 1 time daily, BID = 2 times daily, TID = 3 times daily.​

The Science Explained

Inflammation in the Horse

Diet, Health and Defense Against Inflammation

Protecting a Horse’s Health with Pterostilbene, Curcumin and Antioxidants

Supplementation and Its Role in Equine Health

An In-Depth Look at Nutrition and Cellular Function

The Natural Diet: Feeding for Health


The study of the diet's effect on gene expression.

  • Often investigated in humans with chronic diseases.
  • Studied in animals to determine the effect of different feeds on the level of inflammation in the body and the subsequent development or progression of various diseases.
  • Two important inflammatory markers that are studied are tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ).
  • Though both TNF-α and IFN-γ are required for adequate responses to substances that cause illness or disease, continued or over-expression of TNF-α and IFN-γ can cause the inflammatory responses that characterize various acute and chronic diseases.
  • Increases in TNF-α have been documented in horses with acute traumatic joint disease, osteochondritis dissecans, colic, and laminitis.

The Effect of Omega-3 Fatty Acids on Inflammation

Consumption of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and/or alpha-linolenic acid increases incorporation of omega-3 fatty acids into red blood cells and lowers the expression of the pro-inflammatory cytokines TNF-α and IFN-γ. Reduced inflammatory responses in horses could potentially protect them from inflammation-related chronic diseases. In order to curtail excessive inflammation, it is important to maintain horses on an anti-inflammatory diet high in omega-3 fatty acids. Algae and flax are plant-based sources of omega-3 fatty acids, particularly.

Drug Therapy vs Nutritional Therapy

Most anti-inflammatory drugs block a single point in the enzyme cascade that regulates lipid mediators of inflammation and does so for a short period of time. In contrast, dietary manipulation of the substrates used by these enzymes alters the rate of mediator production by limiting the reactants entering the pathway. As a result dietary modulation is a more flexible and longer lasting method for controlling inflammation.

The Science Behind the Supplements

In a study conducted at the University of California at Davis, percentages of omega-3 and omega-6 fatty acids in red blood cell membranes from five horses were compared before and after six weeks of supplementation*. Supplementation increased the amount of omega-3 fatty acids in the cell membranes by 78%, causing a 40% decrease in the ratio of omega-6 to omega-3 fatty acids.

Researchers at the University of California at Davis conducted an observational study comparing levels of TNF-α and IFN-γ in 63 horses fed different diets. Expression of TNF-α and IFN-γ genes in supplemented* horses consuming oat hay and alfalfa were ~60% lower than horses consuming other feeds. A further regression analysis suggested that individual dietary components significantly impacted expression of TNF-α.

White Papers

Diet, Health and Defense Against Inflammation

Download White Paper

The Natural Diet: Feeding for Health

Download White Paper

Nutrients Beyond the NRC

Download White Paper

Nutrition and Cellular Function

Download White Paper

Protecting a Horse's Health with a Resveratrol Analogue, Antioxidants and Curcumin

Download White Paper

Platinum Performance® Product Flyers

Platinum Performance® Equine Product Flyer

Download Product Flyer

Platinum Performance® CJ Product Flyer

Download Product Flyer

Platinum Longevity™ Product Flyer

Download Product Flyer

Need an Advisor Consultation for Your Clients?

Answers, Recommendations and Support

Our Advisors are trained experts in equine nutrition who can answer tough questions, but most importantly, they care deeply about the health of your patients and are dedicated to providing your clients with the best service possible. Call today 800-553-2400.

Let's Talk