A Critical Role in Supporting Equine Health

The role of oxidative stress in cellular injury and the pathogenesis of many acute and chronic illnesses is a major area of attention and research. It is imperative to prevent exacerbation or prolongation of the bodyʼs responses to this stressor, as it can ultimately result in poor performance, metabolic disturbances, and decreased quality of life.

Various dietary strategies have been designed to combat oxidative stress insults, including anti-oxidant rich diets. In addition, other nutrients can play a significant role in controlling oxidative stress.

Nutritional Solutions to Support Your Patients

See our recommended Platinum Protocols for common equine conditions and injuries.

Condition Products Protocol
Overall Wellness
  • Platinum Performance® Equine or
    Platinum Performance® CJ
Administer 1 scoop of Platinum Performance® Equine or Platinum Performance® CJ BID.
Antioxidant Support
  • Platinum Performance® Equine
  • Vitamin E or
    Platinum Antioxidant or
    Platinum Longevity®
Administer 1 scoop of Platinum Performance® Equine BID and 1 rounded scoop of Vitamin E or 1 rounded scoop of Platinum Antioxidant BID or 1 rounded scoop or 10cc of Platinum Longevity® SID.
  • Platinum Performance® Equine
  • Platinum Performance Antioxidant
Administer 1-2 scoops of Platinum Performance® Equine and 1 rounded scoop of Platinum Antioxidant BID.

SID = 1 time daily, BID = 2 times daily, TID = 3 times daily.​

The Science Explained

The Natural Diet: Feeding for Health

An In-Depth Look at Nutrition and Cellular Function

Feeding to Reduce Oxidative Damage

The Primary Differences Between Pterostilbene and Resveratrol

Nutrients Key to Maintaining Normal,
Healthy Levels of Free Radical Production


  • A compound that is chemically very similar to resveratrol
  • 70-90% bioavailable, whereas resveratrol has a 20-30% absorption rate
  • Remains intact in the blood for up to 7 times longer than resveratrol
  • Can help support analgesic, anti-inflammatory, antioxidant and neuroprotective functions
  • Can help support an increase in the activity of antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and catalase
  • Can help support reductions in MMP-3, an extracellular degradative enzyme, and TNF-α, a systemic inflammatory protein, as well as reductions in the enzyme COX-2


  • The primary active ingredient of turmeric
  • Purportedly has anti-inflammatory, hepato-protective, antioxidant, and anti-carcinogenic properties
  • Suggested therapeutic agent for inflammatory conditions such as inflammatory diseases of the intestinal tract, pancreatitis, and arthritis, as well as cognitive disorders
  • Its biochemical benefits are due, in part, to regulation of transcription factors such as PPAR-γ and NF-kappa β.
  • Affects cytokine and inflammatory markers

Vitamin C

  • Helps support the body's natural defenses against oxidative stress and inflammation
  • Has been shown to help reduce markers of lipid peroxidation and maintain plasma antioxidant capacity in Thoroughbred racehorses

Superoxide Dismutase (SOD)

  • A metalloenzyme that is present in nearly all cells, where it catalyzes the dismutation of superoxide to oxygen and hydrogen peroxide
  • Helps maintain a normal healthy level of free radical production
  • Helps support increased activities of circulating antioxidant enzymes and red blood cell resistance to hemolysis
  • Supports reductions in intestinal tract stress proteins in both humans and animals
  • Helps to maintain resting plasma levels of creatine kinase during intense training

The Science Behind the Supplements

Several studies have proven the positive effect of key antioxidants in reducing the level of oxidative stress in the equine body. In particular, a recent preliminary pilot study characterized biochemical changes in clinically healthy horses before supplementation and after twice daily supplementation with pterostilbene, superoxide dismutase, vitamin C, and curcumin. Results included:

  • A significant decrease in expression of genes for the pro-inflammatory markers: IL-1β, TNF-α, and IL-6
  • A 31% decrease in post-prandial protein carbonyls, a measure of oxidized proteins, was noted in the supplemented group after three weeks of supplementation
  • A significant reduction in lipid peroxidation in fasting blood samples

White Papers

Feeding to Reduce Oxidative Damage to Proteins, Lipids and DNA

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Protecting a Horse’s Health with a Resveratrol Analogue, Antioxidants and Curcumin

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The Natural Diet: Feeding to Optimize the Health of the Horse

Download White Paper

Platinum Performance® Product Flyers

Antioxidant Product Flyer

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Platinum Longevity™ Product Flyer

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Need an Advisor Consultation for Your Clients?

Answers, Recommendations and Support

Our Advisors are trained experts in equine nutrition who can answer tough questions, but most importantly, they care deeply about the health of your patients and are dedicated to providing your clients with the best service possible. Call today 800-553-2400.

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